As the most authoritative, and also the most prestigious science awards, the Nobel prizes in natural science attract more and more attentions. Scholars both at home and abroad, from different viewpoints of humanities and social sciences, such as philosophy, science history and science sociology, make a research and achieve a number of results. This essay, from the perspective of science philosophy, or, to be exact, from the perspective of the scientific knowledge and methodology, and, by a close combination of the detailed information provided by Nobel prizes in natural science, makes an interpretation of the essential concept of the "interdisciplinary". On the one hand, the author traces a brief history of the establishment of this concept, pointing out that the interdisciplinary research, in essence, can be regarded as the breakthrough of the limits between different subjects, or the crossing of the borders between different "modes", or the conversion of different "modes"; and on the other hand, by a statistical analysis of the interdisciplinary research results from the exciting Nobel prizes in natural science, he highlights the development trend of the interdisciplinary natural sciences since the beginning of the 20th century, showing that the significant discoveries and inventions in modern science and technology are mostly resulted in interdisciplinary subjects, and that both major breakthroughs in science and technology and the emergence of new growth points and new subjects are often not be separated from each other' s crossing and infiltration of different subjects, thus underlining the significance of the interdisciplinary research. At the same time, through the examination of the knowledge backgrounds of the Nobel prize winners in natural science, he finds that, since most of winners have a wide range of interests and hobbies, not only being deep but also being profound in scientific knowledge, the interdisciplinary knowledge background can be considered as one of the main factors that stimulate scientists' rich imaginations, break their habits of thinking and obtain original results. What' s more, he has a statistical analysis of the proportion of the cooperative items and winner numbers in different periods, not only displaying the increasing cooperative trend of the research for the Nobel prizes in natural science, but also showing that the wellknown principle of Marx' s economics——"productivity resulted in collaboration——can also be applied to the research for the Nobel prizes in natural science. In a word, the interdisciplinary research not only demands researchers' knowledge background of understanding multidisciplinary crossing, but also relies on scientists' collaboration in various studies.